5 Simple Techniques For LDN-27219 in cancer cell studies
Just one notably exciting compound is LDN-27219. Although most tTG inhibitors are created to bind into the protein crosslinking Energetic web site, LDN-27219 as an alternative binds for the nucleotide binding pocket from the enzyme while it is actually in its closed-condition conformation, and stabilizes that conformation to stop crosslinking activ